L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

Filopodia have a prominent role in driving cancer cell invasion. Here, the authors show that L-type calcium channels are a druggable target regulating filopodia stability and maturation into focal adhesions in metastatic breast cancer cells.

Bibliographic Details
Main Authors: Guillaume Jacquemet, Habib Baghirov, Maria Georgiadou, Harri Sihto, Emilia Peuhu, Pierre Cettour-Janet, Tao He, Merja Perälä, Pauliina Kronqvist, Heikki Joensuu, Johanna Ivaska
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13297

Internet

https://doi.org/10.1038/ncomms13297

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