The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3

The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3

Abstract Background and aim The pathophysiology of rheumatoid arthritis (RA) is characterized by excess production of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) by neutrophils and macrophages in synovium. Additionally, thes...

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Bibliographic Details
Main Authors: Tomotake Kanai, Naoki Kondo, Masayasu Okada, Hiroshige Sano, Go Okumura, Yasufumi Kijima, Akira Ogose, Hiroyuki Kawashima, Naoto Endo
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Low-dose NAC
MMP-3
JNK pathway
MH7A
RA-FLS
Online Access:http://link.springer.com/article/10.1186/s13018-020-01595-9

Internet

http://link.springer.com/article/10.1186/s13018-020-01595-9

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