Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections

Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections

Sirtuin 5 (SIRT5) is a member of the family of NAD+-dependent lysine/histone deacetylases. SIRT5 resides mainly in the mitochondria where it catalyzes deacetylation, demalonylation, desuccinylation, and deglutarylation of lysine to regulate metabolic and oxidative stress response pathways. Pharmacol...

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Bibliographic Details
Main Authors: Tytti Heinonen, Eleonora Ciarlo, Charlotte Théroude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy, Thierry Roger
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
sirtuin
innate immunity
cytokine
macrophage
endotoxemia
sepsis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02675/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02675/full

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