Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia

Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia

Abstract Background Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer’s disease (AD) is related to the inflammatory responses mediat...

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Bibliographic Details
Main Authors: Yoshinori Haraguchi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshiomi Imamura, Toru Murakawa-Hirachi, Hiromi Nabeta, Hiroshi Tateishi, Takahiro A. Kato, Akira Monji
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Calcium
Donepezil
Alzheimer’s disease
Phagocytosis
Nitric oxide
Online Access:http://link.springer.com/article/10.1186/s12974-017-1033-0

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http://link.springer.com/article/10.1186/s12974-017-1033-0

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