FABP4 deactivates NF‐κB‐IL1α pathway by ubiquitinating ATPB in tumor‐associated macrophages and promotes neuroblastoma progression

FABP4 deactivates NF‐κB‐IL1α pathway by ubiquitinating ATPB in tumor‐associated macrophages and promotes neuroblastoma progression

Abstract Neuroblastoma (NB) is the most common and deadliest pediatric solid tumor. Targeting and reactivating tumor‐associated macrophages (TAMs) is necessary for reversing immune suppressive state and stimulating immune defense to exert tumoricidal function. However, studies on the function and re...

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Bibliographic Details
Main Authors: Lei Miao, Zhenjian Zhuo, Jue Tang, Xiaomei Huang, Jiabin Liu, Hai‐Yun Wang, Huimin Xia, Jing He
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Clinical and Translational Medicine
Subjects:
FABP4
neuroblastoma
tumor environment
tumor‐associated macrophages
Online Access:https://doi.org/10.1002/ctm2.395

Internet

https://doi.org/10.1002/ctm2.395

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