Quantification of errors in ordinal outcome scales using shannon entropy: effect on sample size calculations.

Clinical trial outcomes often involve an ordinal scale of subjective functional assessments but the optimal way to quantify results is not clear. In stroke, the most commonly used scale, the modified Rankin Score (mRS), a range of scores ("Shift") is proposed as superior to dichotomization...

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Bibliographic Details
Main Authors: Pitchaiah Mandava, Chase S Krumpelman, Jharna N Shah, Donna L White, Thomas A Kent
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3702531?pdf=render