Display of the HIV envelope protein at the yeast cell surface for immunogen development.

Display of the HIV envelope protein at the yeast cell surface for immunogen development.

As a step toward the development of variant forms of Env with enhanced immunogenic properties, we have expressed the glycoprotein in the yeast surface display system in a form that can be subjected to random mutagenesis followed by screening for forms with enhanced binding to germline antibodies. To...

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Bibliographic Details
Main Authors: Elizabeth Mathew, Hong Zhu, Sara M Connelly, Mark A Sullivan, Matthew G Brewer, Michael S Piepenbrink, James J Kobie, Stephen Dewhurst, Mark E Dumont
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6193675?pdf=render

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http://europepmc.org/articles/PMC6193675?pdf=render

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