EPC-Derived Exosomal miR-1246 and miR-1290 Regulate Phenotypic Changes of Fibroblasts to Endothelial Cells to Exert Protective Effects on Myocardial Infarction by Targeting ELF5 and SP1

EPC-Derived Exosomal miR-1246 and miR-1290 Regulate Phenotypic Changes of Fibroblasts to Endothelial Cells to Exert Protective Effects on Myocardial Infarction by Targeting ELF5 and SP1

Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. Endothelial progenitor cell (EPC)-derived exosomes have been found to be effective in alleviating MI, while the detailed mechanisms remain unclear. The present study aimed to determine the protective effects of...

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Bibliographic Details
Main Authors: Yulang Huang, Lifang Chen, Zongming Feng, Weixin Chen, Shaodi Yan, Rongfeng Yang, Jian Xiao, Jiajia Gao, Debao Zhang, Xiao Ke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
EPC-derived exosomes
fibroblast-endothelial transition
miR-1246
miR-1290
ELF5
SP1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.647763/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.647763/full

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