EPC-Derived Exosomal miR-1246 and miR-1290 Regulate Phenotypic Changes of Fibroblasts to Endothelial Cells to Exert Protective Effects on Myocardial Infarction by Targeting ELF5 and SP1

EPC-Derived Exosomal miR-1246 and miR-1290 Regulate Phenotypic Changes of Fibroblasts to Endothelial Cells to Exert Protective Effects on Myocardial Infarction by Targeting ELF5 and SP1

Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. Endothelial progenitor cell (EPC)-derived exosomes have been found to be effective in alleviating MI, while the detailed mechanisms remain unclear. The present study aimed to determine the protective effects of...

Full description

Bibliographic Details
Main Authors: Yulang Huang, Lifang Chen, Zongming Feng, Weixin Chen, Shaodi Yan, Rongfeng Yang, Jian Xiao, Jiajia Gao, Debao Zhang, Xiao Ke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
EPC-derived exosomes
fibroblast-endothelial transition
miR-1246
miR-1290
ELF5
SP1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.647763/full

Similar Items

Similar Items