Optimization of Liposomes for Antigen Targeting to Splenic CD169<sup>+</sup> Macrophages

Optimization of Liposomes for Antigen Targeting to Splenic CD169<sup>+</sup> Macrophages

Despite promising progress in cancer vaccination, therapeutic effectiveness is often insufficient. Cancer vaccine effectiveness could be enhanced by targeting vaccine antigens to antigen-presenting cells, thereby increasing T-cell activation. CD169-expressing splenic macrophages efficiently capture...

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Bibliographic Details
Main Authors: Maarten K. Nijen Twilhaar, Lucas Czentner, Joanna Grabowska, Alsya J. Affandi, Chun Yin Jerry Lau, Katarzyna Olesek, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M.M. den Haan
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
cancer vaccination
liposome
targeting
GM3
macrophage
CD169
Online Access:https://www.mdpi.com/1999-4923/12/12/1138

Internet

https://www.mdpi.com/1999-4923/12/12/1138

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