Optimal Tolerogenic Dendritic Cells in Type 1 Diabetes (T1D) Therapy: What Can We Learn From Non-obese Diabetic (NOD) Mouse Models?

Optimal Tolerogenic Dendritic Cells in Type 1 Diabetes (T1D) Therapy: What Can We Learn From Non-obese Diabetic (NOD) Mouse Models?

Tolerogenic dendritic cells (tolDCs) are explored as a promising standalone or combination therapy in type 1 diabetes (T1D). The therapeutic application of tolDCs, including in human trials, has been tested also in other autoimmune diseases, however, T1D displays some unique features. In addition, u...

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Bibliographic Details
Main Authors: David P. Funda, Lenka Palová-Jelínková, Jaroslav Goliáš, Zuzana Kroulíková, Alena Fajstová, Tomáš Hudcovic, Radek Špíšek
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
cell therapy
animal models
tolerogenic dendritic cells
NOD mouse
protocol optimization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00967/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00967/full

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