Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Because of poor solubility and considerable metabolism, vardenafil (VRD) bioavailability is 15%. To overcome this obstacle, this study aimed to increase the solubility, hasten the onset of action, and mask the unpleasant taste of VRD utilizing β-cyclodextrin (β-CD) and formulation...

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Bibliographic Details
Main Authors: Hytham A. Al-Gethmy, Usama A. Fahmy, Nabil A. Alhakamy, Osama A. A. Ahmed, Khalid M. El-Say
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Pharmaceutics
Subjects:
bioavailability
Box–Behnken design
β-cyclodextrin
erectile dysfunction
taste masking
vardenafil
Online Access:http://www.mdpi.com/1999-4923/11/1/11

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http://www.mdpi.com/1999-4923/11/1/11

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