Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R

Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R

Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C virus (HCV), a unique, oncogenic RNA virus that is the leading infectious cause of liver cancer...

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Bibliographic Details
Main Authors: Jonathan K. Mitchell, Bentley R. Midkiff, Benjamin Israelow, Matthew J. Evans, Robert E. Lanford, Christopher M. Walker, Stanley M. Lemon, David R. McGivern, Vincent R. Racaniello
Format: Article
Language:English
Published: American Society for Microbiology 2017-04-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/2/e00121-17

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http://mbio.asm.org/cgi/content/full/8/2/e00121-17

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