Translation in amino-acid-poor environments is limited by tRNAGln charging

An inadequate supply of amino acids leads to accumulation of uncharged tRNAs, which can bind and activate GCN2 kinase to reduce translation. Here, we show that glutamine-specific tRNAs selectively become uncharged when extracellular amino acid availability is compromised. In contrast, all other tRNA...

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Bibliographic Details
Main Authors: Natalya N Pavlova, Bryan King, Rachel H Josselsohn, Sara Violante, Victoria L Macera, Santosha A Vardhana, Justin R Cross, Craig B Thompson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/62307