Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment.

Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment.

PIK3CA upregulation, amplification and mutation have been widely reported in ovarian cancers and other tumors, which strongly suggests that PIK3CA is a promising therapeutic target. However, to date the mechanisms underlying PIK3CA regulation and activation in vivo is still unclear. During tumorigen...

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Bibliographic Details
Main Authors: Nuo Yang, Jia Huang, Joel Greshock, Shun Liang, Andrea Barchetti, Kosei Hasegawa, Sarah Kim, Antonis Giannakakis, Chunsheng Li, Anne O'Brien-Jenkins, Dionyssios Katsaros, Ralf Bützow, George Coukos, Lin Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2258145?pdf=render

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http://europepmc.org/articles/PMC2258145?pdf=render

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