Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.

Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.

Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, inhibiting translation, and increasing expression of chaperones that enhance ER...

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Bibliographic Details
Main Authors: Vyacheslav M Labunskyy, Maxim V Gerashchenko, Joe R Delaney, Alaattin Kaya, Brian K Kennedy, Matt Kaeberlein, Vadim N Gladyshev
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3879150?pdf=render

Internet

http://europepmc.org/articles/PMC3879150?pdf=render

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