Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

Abstract Background Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer’s disease (AD). Activation of DAMs is dependent on triggering receptor expressed on myeloid cells 2 (TREM2) in mouse models and the AD T...

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Bibliographic Details
Main Authors: Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E. England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C. Spitale, Hayk Davtyan, Mathew Blurton-Jones
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Neurodegeneration
Subjects:
TREM2
Human microglia
Chimeric Alzheimer mice
Lipid droplets
Online Access:https://doi.org/10.1186/s13024-021-00473-0

Internet

https://doi.org/10.1186/s13024-021-00473-0

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