NAD-Glycohydrolase Depletes Intracellular NAD+ and Inhibits Acidification of Autophagosomes to Enhance Multiplication of Group A Streptococcus in Endothelial Cells

NAD-Glycohydrolase Depletes Intracellular NAD+ and Inhibits Acidification of Autophagosomes to Enhance Multiplication of Group A Streptococcus in Endothelial Cells

Group A Streptococcus (GAS) is a human pathogen causing a wide spectrum of diseases, from mild pharyngitis to life-threatening necrotizing fasciitis. GAS has been shown to evade host immune killing by invading host cells. However, how GAS resists intracellular killing by endothelial cells is still u...

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Bibliographic Details
Main Authors: Cheng-Lu Hsieh, Hsuan-Min Huang, Shu-Ying Hsieh, Po-Xing Zheng, Yee-Shin Lin, Chuan Chiang-Ni, Pei-Jane Tsai, Shu-Ying Wang, Ching-Chuan Liu, Jiunn-Jong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Microbiology
Subjects:
group A Streptococcus
NADase
NAD+ balance
acidification
intracellular multiplication
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01733/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01733/full

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