Intron-targeted mutagenesis reveals roles for Dscam1 RNA pairing architecture-driven splicing bias in neuronal wiring

Intron-targeted mutagenesis reveals roles for Dscam1 RNA pairing architecture-driven splicing bias in neuronal wiring

Summary: Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam1) can generate 38,016 different isoforms through largely stochastic, yet highly biased, alternative splicing. These isoforms are required for nervous functions. However, the functional significance of splicing bias remains...

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Bibliographic Details
Main Authors: Weiling Hong, Jian Zhang, Haiyang Dong, Yang Shi, Hongru Ma, Fengyan Zhou, Bingbing Xu, Ying Fu, Shixin Zhang, Shouqing Hou, Guo Li, Yandan Wu, Shuo Chen, Xiaohua Zhu, Wendong You, Feng Shi, Xiaofeng Yang, Zhefeng Gong, Jianhua Huang, Yongfeng Jin
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
Dscam
isoform diversity
alternative splicing
splicing bias
neuronal wiring
self-avoidance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007713

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http://www.sciencedirect.com/science/article/pii/S2211124721007713

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