Endocytosis of DNA-Hsp65 alters the pH of the late endosome/lysosome and interferes with antigen presentation.

Endocytosis of DNA-Hsp65 alters the pH of the late endosome/lysosome and interferes with antigen presentation.

BACKGROUND: Experimental models using DNA vaccine has shown that this vaccine is efficient in generating humoral and cellular immune responses to a wide variety of DNA-derived antigens. Despite the progress in DNA vaccine development, the intracellular transport and fate of naked plasmid DNA in euka...

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Bibliographic Details
Main Authors: Ana Paula F Trombone, Célio L Silva, Karla M Lima, Constance Oliver, Maria Célia Jamur, Alan R Prescott, Arlete A M Coelho-Castelo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1976595?pdf=render

Internet

http://europepmc.org/articles/PMC1976595?pdf=render

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