Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

Abstract Background Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunits p110γ and p110δ of PI3Kγ and PI3Kδ in p110γ/δ−/− mice leads to defect...

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Bibliographic Details
Main Authors: Kirsten Bucher, Fee Schmitt, Benedikt Mothes, Carolin Blumendeller, Daniel Schäll, Roland Piekorz, Emilio Hirsch, Bernd Nürnberg, Sandra Beer-Hammer
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Cell Communication and Signaling
Subjects:
PI3K p110γ
PI3K p110δ,neutrophil homeostasis
IL-17-producing T cells
Il-17
G-CSF
Online Access:http://link.springer.com/article/10.1186/s12964-017-0185-y

Internet

http://link.springer.com/article/10.1186/s12964-017-0185-y

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