Targeting POLE2 Creates a Novel Vulnerability in Renal Cell Carcinoma via Modulating Stanniocalcin 1

Targeting POLE2 Creates a Novel Vulnerability in Renal Cell Carcinoma via Modulating Stanniocalcin 1

ObjectiveThe aim of this study is to investigate the biological functions and the underlying mechanisms of DNA polymerase epsilon subunit 2 (POLE2) in renal cell carcinoma (RCC).MethodsThe datasets of POLE2 expression in The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) and Internation...

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Bibliographic Details
Main Authors: Chuanjie Zhang, Yan Shen, Lili Gao, Xiaojing Wang, Da Huang, Xin Xie, Danfeng Xu, Hongchao He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
POLE2
renal cell carcinoma
proliferation
migration
stanniocalcin 1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.622344/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.622344/full

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