Identification of Modifier Genes in a Mouse Model of Gaucher Disease

Identification of Modifier Genes in a Mouse Model of Gaucher Disease

Diseases caused by single-gene mutations can display substantial phenotypic variability, which may be due to genetic, environmental, or epigenetic modifiers. Here, we induce Gaucher disease (GD), a rare inherited metabolic disorder, by injecting 15 inbred mouse strains with a low dose of a chemical...

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Bibliographic Details
Main Authors: Andrés D. Klein, Natalia-Santos Ferreira, Shifra Ben-Dor, Jingjing Duan, John Hardy, Timothy M. Cox, Alfred H. Merrill Jr., Anthony H. Futerman
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716310324

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http://www.sciencedirect.com/science/article/pii/S2211124716310324

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