MUREN: a robust and multi-reference approach of RNA-seq transcript normalization

Abstract Background Normalization of RNA-seq data aims at identifying biological expression differentiation between samples by removing the effects of unwanted confounding factors. Explicitly or implicitly, the justification of normalization requires a set of housekeeping genes. However, the existen...

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Bibliographic Details
Main Authors: Yance Feng, Lei M. Li
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-021-04288-0