Lobeglitazone Attenuates Airway Inflammation and Mucus Hypersecretion in a Murine Model of Ovalbumin-Induced Asthma

Lobeglitazone Attenuates Airway Inflammation and Mucus Hypersecretion in a Murine Model of Ovalbumin-Induced Asthma

Lobeglitazone (LB) is a novel agonist of peroxisome proliferator-activated receptor (PPAR)-α and γ that was developed as a drug to treat diabetes mellitus. We explored the ameliorative effects of LB on allergic asthma using a murine model of ovalbumin (OVA)-induced asthma. To boost the immune respon...

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Bibliographic Details
Main Authors: Na-Rae Shin, Sung-Hyeuk Park, Je-Won Ko, Young-Kwon Cho, In-Chul Lee, Jong-Choon Kim, In-Sik Shin, Joong-Sun Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
lobeglitazone
asthma
peroxisome proliferator-activated receptor
airway inflammation
mucus hypersecretion
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00906/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00906/full

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