Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis

Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis

The activation of TLR7 signaling in T cells accelerates antigen-specific responses. Such responses play an essential role in eliminating viral infections and can be anti-tumorigenic. However, the underlying mechanisms of how TLR7 can promote the optimal function of CD8+ T cells remain unclear. To in...

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Bibliographic Details
Main Authors: Qian Li, Yan Yan, Jia Liu, Xuan Huang, Xiaoyong Zhang, Carsten Kirschning, Haifeng C. Xu, Philipp A. Lang, Ulf Dittmer, Ejuan Zhang, Mengji Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
toll-like receptor 7
CD8+ T cells
PI3K-Akt-mTOR
glycolysis
IRF4
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02191/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02191/full

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