Sitagliptin Modulates Oxidative, Nitrative and Halogenative Stress and Inflammatory Response in Rat Model of Hepatic Ischemia-Reperfusion

Sitagliptin Modulates Oxidative, Nitrative and Halogenative Stress and Inflammatory Response in Rat Model of Hepatic Ischemia-Reperfusion

A possibility of repurposing sitagliptin, a well-established antidiabetic drug, for alleviating injury caused by ischemia-reperfusion (IR) is being researched. The aim of this study was to shed some light on the molecular background of the protective activity of sitagliptin during hepatic IR. The ex...

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Bibliographic Details
Main Authors: Małgorzata Trocha, Mariusz G. Fleszar, Paulina Fortuna, Łukasz Lewandowski, Kinga Gostomska-Pampuch, Tomasz Sozański, Anna Merwid-Ląd, Małgorzata Krzystek-Korpacka
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Antioxidants
Subjects:
drug repurposing
dipeptidylpeptidase-4 antagonists
midkine
bromotyrosine
nitrotyrosine
liver transplantation
Online Access:https://www.mdpi.com/2076-3921/10/8/1168

Internet

https://www.mdpi.com/2076-3921/10/8/1168

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