Reporter cell lines to evaluate the selectivity of chemicals for human and zebrafish estrogen and peroxysome proliferator activated γ receptors

Reporter cell lines to evaluate the selectivity of chemicals for human and zebrafish estrogen and peroxysome proliferator activated γ receptors

Zebrafish is increasingly used as an animal model to study the effects of environmental nuclear receptors (NRs) ligands. As most of these compounds have only been tested on human NRs, it is necessary to measure their effects on zebrafish NRs. Estrogen receptors (ER) α and β and peroxysome proliferat...

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Bibliographic Details
Main Authors: Marina eGrimaldi, Abdelhay eBoulahtouf, Vanessa eDelfosse, Erwan eThouennon, William eBourguet, Patrick eBalaguer
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Neuroscience
Subjects:
Zebrafish
human
estrogen receptor
Reporter cell lines
peroxysome proliferator activated receptor γ
environmental disrupting compounds
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00212/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00212/full

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