β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery

β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery

Extrahepatic tissues which oxidise ketone bodies also have the capacity to accumulate them under particular conditions. We hypothesised that acetyl-coenzyme A (acetyl-CoA) accumulation and altered redox status during low-flow ischaemia would support ketone body production in the heart. Combining a L...

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Bibliographic Details
Main Authors: Ross T Lindsay, Sophie Dieckmann, Dominika Krzyzanska, Dominic Manetta-Jones, James A West, Cecilia Castro, Julian L Griffin, Andrew J Murray
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
Heart
Langendorff
cardiomyocyte
Ischaemia
Online Access:https://elifesciences.org/articles/71270

Internet

https://elifesciences.org/articles/71270

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