MEM: An Algorithm for the Reliable Detection of Microsatellite Instability (MSI) on a Small NGS Panel in Colorectal Cancer

MEM: An Algorithm for the Reliable Detection of Microsatellite Instability (MSI) on a Small NGS Panel in Colorectal Cancer

Purpose: MEM is an NGS algorithm that uses Expectation-Maximisation to detect the presence of unstable alleles from the NGS sequences of five microsatellites (BAT-25, BAT-26, NR-21, NR-24 and NR-27). The purpose of this study was to compare the MEM algorithm with a reference PCR method (MSI-PCR) and...

Full description

Bibliographic Details
Main Authors: Guillaume Herbreteau, Fabrice Airaud, Elise Pierre-Noël, Audrey Vallée, Stéphane Bézieau, Sandrine Théoleyre, Hélène Blons, Simon Garinet, Marc Guillaume Denis
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
microsatellite instability
deficient mismatch repair system
colorectal cancer
NGS
expectation-maximisation algorithm
Online Access:https://www.mdpi.com/2072-6694/13/16/4203

Internet

https://www.mdpi.com/2072-6694/13/16/4203

Similar Items