Preferential Binding of Mg2+ Over Ca2+ to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J

Preferential Binding of Mg2+ Over Ca2+ to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J

Calcium and integrin binding protein 2 (CIB2) shares with the other members of the CIB family the ability to bind Ca2+ and Mg2+ via two functional EF-hand motifs, namely EF3 and EF4. As a cation sensor, CIB2 is able to switch to a conformation likely associated with specific biological functions yet...

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Bibliographic Details
Main Authors: Rosario Vallone, Giuditta Dal Cortivo, Mariapina D'Onofrio, Daniele Dell'Orco
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
calcium sensor
Usher syndrome 1J
DFNB48
nuclear magnetic resonance
hearing loss
calcium and integrin binding protein
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00274/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00274/full

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