Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19

Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19

The human cytochrome P450 (CYP) 2C9 and 2C19 enzymes are two highly similar isoforms with key roles in drug metabolism. They are anchored to the endoplasmic reticulum membrane by their N-terminal transmembrane helix and interactions of their cytoplasmic globular domain with the membrane. However, th...

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Bibliographic Details
Main Authors: Ghulam Mustafa, Prajwal P. Nandekar, Neil J. Bruce, Rebecca C. Wade
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
cytochrome P450
isoform
membrane protein
protein-membrane interactions
enzyme substrate specificity
mutagenesis
molecular dynamics simulation
Online Access:https://www.mdpi.com/1422-0067/20/18/4328

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https://www.mdpi.com/1422-0067/20/18/4328

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