ICP0 antagonizes ICP4-dependent silencing of the herpes simplex virus ICP0 gene.

ICP0 antagonizes ICP4-dependent silencing of the herpes simplex virus ICP0 gene.

ICP0 is a regulatory protein that plays a critical role in the replication-latency balance of herpes simplex virus (HSV). Absence of ICP0 renders HSV prone to establish quiescent infections, and thus cellular repressor(s) are believed to silence HSV mRNA synthesis when ICP0 fails to accumulate. To d...

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Bibliographic Details
Main Authors: Mingyu Liu, Brandon Rakowski, Edward Gershburg, Carla M Weisend, Olivier Lucas, Edward E Schmidt, William P Halford
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2809113?pdf=render

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http://europepmc.org/articles/PMC2809113?pdf=render

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