DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits

DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits

The loss of native function of the DJ-1 protein has been linked to the development of Parkinson's (PD) and other neurodegenerative diseases. Here we show that DJ-1 aggregates into β-sheet structured soluble and fibrillar aggregates in vitro under physiological conditions and that this process i...

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Bibliographic Details
Main Authors: Katalin Solti, Wei-Li Kuan, Balázs Fórizs, Gergely Kustos, Judith Mihály, Zoltán Varga, Balázs Herberth, Éva Moravcsik, Róbert Kiss, Manuela Kárpáti, Anna Mikes, Yanyan Zhao, Tímea Imre, Jean-Christophe Rochet, Franklin Aigbirhio, Caroline H. Williams-Gray, Roger A. Barker, Gergely Tóth
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Subjects:
DJ-1
Parkinson's
Alzheimer's
Aggregation
Amyloid
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303043

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http://www.sciencedirect.com/science/article/pii/S0969996119303043

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