Hypomethylation mediates genetic association with the major histocompatibility complex genes in Sjögren's syndrome.

Hypomethylation mediates genetic association with the major histocompatibility complex genes in Sjögren's syndrome.

Differential methylation of immune genes has been a consistent theme observed in Sjögren's syndrome (SS) in CD4+ T cells, CD19+ B cells, whole blood, and labial salivary glands (LSGs). Multiple studies have found associations supporting genetic control of DNA methylation in SS, which in the abs...

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Bibliographic Details
Main Authors: Calvin Chi, Kimberly E Taylor, Hong Quach, Diana Quach, Lindsey A Criswell, Lisa F Barcellos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0248429

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https://doi.org/10.1371/journal.pone.0248429

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