The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form

The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form

Along with Parkin, PINK1 plays a critical role in maintaining mitochondrial quality control. Although PINK1 is expressed constitutively, its level is kept low in healthy mitochondria by polyubiquitination and ensuing proteasomal degradation of its mature, 52 kDa, form. We show here that the target o...

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Bibliographic Details
Main Authors: Yuhui Liu, Cristina Guardia-Laguarta, Jiang Yin, Hediye Erdjument-Bromage, Brittany Martin, Michael James, Xuejun Jiang, Serge Przedborski
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
PINK1
ubiquitination
mitochondria
Parkinson’s disease
mitophagy
proteasome
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308197

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http://www.sciencedirect.com/science/article/pii/S2211124717308197

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