HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner

HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner

Abstract Background Human Papillomavirus (HPV) infection is the main risk factor for the development and progression of cervical cancer. HPV-16 E6 and E7 expression is essential for induction and maintenance of the transformed phenotype. These oncoproteins interfere with the function of several intr...

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Bibliographic Details
Main Authors: Tatiana Rabachini, Enrique Boccardo, Rubiana Andrade, Katia Regina Perez, Suely Nonogaki, Iolanda Midea Cuccovia, Luisa Lina Villa
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
HPV
E7
PLD
Phospholipase
Rapamycin
Phosphatidic acid
Online Access:http://link.springer.com/article/10.1186/s12885-018-4392-8

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http://link.springer.com/article/10.1186/s12885-018-4392-8

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