Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm

Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm

SUMMARY Atrial fibrillation (AF) is the most common cardiac arrhythmia and carries a significant risk of stroke and heart failure. The molecular etiologies of AF are poorly understood, leaving patients with limited therapeutic options. AF has been recognized as an inherited disease in almost 30% of...

Full description

Bibliographic Details
Main Authors: Iris I. Müller, David B. Melville, Vineeta Tanwar, Witold M. Rybski, Amrita Mukherjee, M. Benjamin Shoemaker, Wan-Der Wang, John A. Schoenhard, Dan M. Roden, Dawood Darbar, Ela W. Knapik, Antonis K. Hatzopoulos
Format: Article
Language:English
Published: The Company of Biologists 2013-03-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/2/332

Internet

http://dmm.biologists.org/content/6/2/332

Similar Items