Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction

Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction

Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether impaired vascular redox biology resulting of increa...

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Bibliographic Details
Main Authors: Lucas C. Pinheiro, Gustavo H. Oliveira-Paula, Rafael L. Portella, Danielle A. Guimarães, Celio D. de Angelis, Jose E. Tanus-Santos
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Redox Biology
Subjects:
Endothelial dysfunction
Omeprazole
Oxidative stress
Proton pump inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S221323171630060X

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http://www.sciencedirect.com/science/article/pii/S221323171630060X

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