Mechanistic insights into Lp(a)-induced IL-8 expression: a role for oxidized phospholipid modification of apo(a)

Mechanistic insights into Lp(a)-induced IL-8 expression: a role for oxidized phospholipid modification of apo(a)

Elevated lipoprotein (a) [Lp(a)] levels are a causal risk factor for coronary heart disease. Accumulating evidence suggests that Lp(a) can stimulate cellular inflammatory responses through the kringle-containing apolipoprotein (a) [apo(a)] component. Here, we report that recombinant apo(a) containin...

Full description

Bibliographic Details
Main Authors: Corey A. Scipione, Sera E. Sayegh, Rocco Romagnuolo, Sotirios Tsimikas, Santica M. Marcovina, Michael B. Boffa, Marlys L. Koschinsky
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Journal of Lipid Research
Subjects:
lipoprotein (a)
atherosclerosis
interleukin-8
inflammation
apolipoprotein (a)
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309470

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520309470

Similar Items