The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS

The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord. Mutations in the Cu/Zn superoxide dismutase (SOD1) gene account for ~20% of all familial ALS forms, corresponding to 1%–2% of all ALS cases. One of the su...

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Bibliographic Details
Main Authors: Yulia Dzhashiashvili, Chase P. Monckton, Harini S. Shah, Rejani B. Kunjamma, Brian Popko
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
SOD1 mice
Motor neurons
Endoplasmic reticulum stress
Unfolded protein response
PERK
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300774

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http://www.sciencedirect.com/science/article/pii/S0969996119300774

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