Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo.

Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo.

Lymphocyte Activation Gene - 3 (LAG-3) is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. However, the molecular mechanisms underlying LAG-3's function are generally unknown. Using a model in which LAG-3 blockade or absence reliably augmented homeostatic pro...

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Bibliographic Details
Main Authors: Nicholas M Durham, Christopher J Nirschl, Christopher M Jackson, Jimmy Elias, Christina M Kochel, Robert A Anders, Charles G Drake
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4220939?pdf=render

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http://europepmc.org/articles/PMC4220939?pdf=render

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