MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. Here we show that MYBL2, a gene within the 20q CDR, is expressed at sharply reduced levels in C...

Full description

Bibliographic Details
Main Authors: Stefan Heinrichs, Lillian F Conover, Carlos E Bueso-Ramos, Outi Kilpivaara, Kristen Stevenson, Donna Neuberg, Mignon L Loh, Wen-Shu Wu, Scott J Rodig, Guillermo Garcia-Manero, Hagop M Kantarjian, A Thomas Look
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-07-01
Series:eLife
Subjects:
Myelodysplastic Syndromes
MYBL2
20q CDR
Online Access:https://elifesciences.org/articles/00825

Internet

https://elifesciences.org/articles/00825

Similar Items