Identification of Immunological Parameters as Predictive Biomarkers of Relapse in Patients with Chronic Myeloid Leukemia on Treatment-Free Remission

Identification of Immunological Parameters as Predictive Biomarkers of Relapse in Patients with Chronic Myeloid Leukemia on Treatment-Free Remission

BCR-ABL is an aberrant tyrosine kinase responsible for chronic myeloid leukemia (CML). Tyrosine kinase inhibitors (TKIs) induce a potent antileukemic response mostly based on the inhibition of BCR-ABL, but they also increase the activity of Natural Killer (NK) and CD8+ T cells. After several years,...

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Bibliographic Details
Main Authors: Lorena Vigón, Alejandro Luna, Miguel Galán, Sara Rodríguez-Mora, Daniel Fuertes, Elena Mateos, Miguel Piris-Villaespesa, Guiomar Bautista, Esther San José, José Rivera-Torres, Juan Luis Steegmann, Fernando de Ory, Mayte Pérez-Olmeda, José Alcamí, Vicente Planelles, María Rosa López-Huertas, Valentín García-Gutiérrez, Mayte Coiras
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Journal of Clinical Medicine
Subjects:
chronic myeloid leukemia
treatment-free remission
immunological response
Online Access:https://www.mdpi.com/2077-0383/10/1/42

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https://www.mdpi.com/2077-0383/10/1/42

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