Genetic dynamics in untreated CLL patients with either stable or progressive disease: a longitudinal study

Genetic dynamics in untreated CLL patients with either stable or progressive disease: a longitudinal study

Abstract Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggre...

Full description

Bibliographic Details
Main Authors: Alice Ramassone, Andrea D’Argenio, Angelo Veronese, Alessio Basti, Shimaa Hassan AbdelAziz Soliman, Stefano Volinia, Cristian Bassi, Sara Pagotto, Manuela Ferracin, Laura Lupini, Elena Saccenti, Veronica Balatti, Felice Pepe, Laura Z. Rassenti, Idanna Innocenti, Francesco Autore, Laura Marzetti, Renato Mariani-Costantini, Thomas J. Kipps, Massimo Negrini, Luca Laurenti, Rosa Visone
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Hematology & Oncology
Subjects:
Chronic lymphocytic leukemia
Copy number variation
Nucleotide variation
Clonal evolution
Online Access:http://link.springer.com/article/10.1186/s13045-019-0802-x

Internet

http://link.springer.com/article/10.1186/s13045-019-0802-x

Similar Items