The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation.

The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation.

Lipopolysaccharide (LPS) is a potent microbial virulence factor that can trigger production of proinflammatory mediators involved in the pathogenesis of localized and systemic inflammation. Importantly, the role of nuclear transport of stress responsive transcription factors in this LPS-generated &q...

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Bibliographic Details
Main Authors: Antonio DiGiandomenico, Ruth Ann Veach, Jozef Zienkiewicz, Daniel J Moore, Lukasz S Wylezinski, Martha A Hutchens, Jacek Hawiger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4203769?pdf=render

Internet

http://europepmc.org/articles/PMC4203769?pdf=render

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