Trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme II by N-allyl and N-propyl oxamates and their effects on intact epimastigotes

Trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme II by N-allyl and N-propyl oxamates and their effects on intact epimastigotes

N-allyl (NAOx) and N-propyl (NPOx) oxamates were designed as inhibitors of alpha-hydroxyacid dehydrogenase (HADH) isozyme II from Trypanosoma cruzi. The kinetic studies showed that NAOx and NPOx were competitive inhibitors of HADH-isozyme II (Ki = 72 µM, IC50 = 0.33 mM and 70 µM, IC50 = 0.32 mM, res...

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Bibliographic Details
Main Authors: Miguel A Chena, Silvia Elizondo-Jiménez, Lorena Rodríguez-Páez, Benjamín Nogueda-Torres, Isabel Baeza-Ramírez, Carlos Wong-Ramírez
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2004-12-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Trypanosoma cruzi
Trypanosoma cruzi alpha-hydroxyacid dehydrogenase-isozyme II inhibition
N-allyl oxamate
N-propyl oxamate
ethyl N-propyl oxamate
ethyl N-allyl oxamate
alpha-hydroxyacid dehydrogenase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000800009

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