Low-Affinity T Cells Are Programmed to Maintain Normal Primary Responses but Are Impaired in Their Recall to Low-Affinity Ligands

Low-Affinity T Cells Are Programmed to Maintain Normal Primary Responses but Are Impaired in Their Recall to Low-Affinity Ligands

T cell responses to low-affinity T cell receptor (TCR) ligands occur in the context of infection, tumors, and autoimmunity despite diminished TCR signal strength. The processes that enable such responses remain unclear. We show that distinct mechanisms drive effector/memory development in high- and...

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Bibliographic Details
Main Authors: Karin M. Knudson, Nicholas P. Goplen, Cody A. Cunningham, Mark A. Daniels, Emma Teixeiro
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003550

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http://www.sciencedirect.com/science/article/pii/S2211124713003550

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