Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.

Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.

PURPOSE: To explore the effects of Icaritin on chronic myeloid leukemia (CML) cells and underlying mechanisms. METHOD: CML cells were incubated with various concentration of Icaritin for 48 hours, the cell proliferation was analyzed by MTT and the apoptosis was assessed with Annexin V and Hoechst 33...

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Main Authors: Jian feng Zhu, Zi jian Li, Guang sen Zhang, Kun Meng, Wen yong Kuang, Jin Li, Xin fu Zhou, Rui juan Li, Hong ling Peng, Chong wen Dai, Jian Kai Shen, Fan jie Gong, Yun xiao Xu, Su fang Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3161749?pdf=render

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http://europepmc.org/articles/PMC3161749?pdf=render

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