Efficient and Non-genotoxic RNA-Based Engineering of Human T Cells Using Tumor-Specific T Cell Receptors With Minimal TCR Mispairing

Efficient and Non-genotoxic RNA-Based Engineering of Human T Cells Using Tumor-Specific T Cell Receptors With Minimal TCR Mispairing

Genetic engineering of T cells with tumor specific T-cell receptors (TCR) is a promising strategy to redirect their specificity against cancer cells in adoptive T cell therapy protocols. Most studies are exploiting integrating retro- or lentiviral vectors to permanently introduce the therapeutic TCR...

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Bibliographic Details
Main Authors: Diana Campillo-Davo, Fumihiro Fujiki, Johan M. J. Van den Bergh, Hans De Reu, Evelien L. J. M. Smits, Herman Goossens, Haruo Sugiyama, Eva Lion, Zwi N. Berneman, Viggo Van Tendeloo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
TCR-gene transfer
electroporation
adoptive cell therapy (ACT)
DsiRNA
RNA transfection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02503/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02503/full

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